The Sanitarium, first established in the 1880’s as a place of health and restoration, is now re-created to offer a fresh perspective on travel accommodations. This intimate guest house, walking distance from downtown San Luis Obispo, is the perfect place to stay while visiting our famous wineries, beaches and art galleries. The traveler seeking a unique experience will be inspired by the luxe Sanitarium, where funky meets luxury, and our bon vivant innkeepers make guests feel like friends.